doi:10.3850/978-981-07-0319-6_248

ABSTRACT

A new concept of injection moulded polymer microneedle arrays serving as an interface to the human vascular system was developed. By applying injection moulding, low cost disposables can be manufactured and biocompatibility can be ensured with appropriate polymers. Main design targets of the microneedles are easy application, low puncture force, reliable sealing and pressure driven dosage. During the development process, different microneedle arrays were designed. Due to a specially designed geometry, the puncture force of the microneedles could be significantly reduced. Additionally, placement of the microneedles on top of small sockets enabled simple manual insertion into the skin. A stable moulding process with the fabricated moulding tools was demonstrated. Precisely replicated parts featuring very sharp cutting edges were manufactured. Experimental characterisation of injection moulded arrays showed sufficient mechanical stability as well as encouraging first results in ex and in vivo application tests.

Keywords: Microneedle, Injection moulding, Vascular system, Reduced puncture force, Dosage.

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