The Study of Micro- and Macro-structural Features of Silk Fibroin Scaffolds

doi:10.3850/978-981-08-7615-9_TE08

The Study of Micro- and Macro-structural Features of Silk Fibroin Scaffolds

Mei Jun Jolene Liu¹, Siaw Meng Chou¹, Chee Kai Chua¹, Chia Meng Benjamin Tay² and Beng Koon Ng²

¹Nanyang Technological University, School of Mechanical and Aerospace Engineering, Singapore

²School of Electrical and Electronic Engineering, Singapore

ABSTRACT

The purpose of this study is to investigate on the micro-structure of 10 and 20.5% (wt/wt) silk fibroin (SF) foams using spectral domain-optical coherence tomography (SD-OCT). Due to the scattering nature of SF, the non-cylindrical pore models of the created foams were identified and measured. The presence of the macro internal channels within Rapid Prototyping (RP)-fabricated SF tissue scaffolds was also verified using the advanced imaging tool. Despite the inability to discriminate the difference between the SF and cultured cell layers as a result of short culture period, the seeded cells were observed to migrate and proliferate consistently in different regions of the SF scaffolds.

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The Study of Micro- and Macro-structural Features of Silk Fibroin Scaffolds

Mei Jun Jolene Liu1, Siaw Meng Chou1, Chee Kai Chua1, Chia Meng Benjamin Tay2 and Beng Koon Ng2

1Nanyang Technological University, School of Mechanical and Aerospace Engineering, Singapore

2School of Electrical and Electronic Engineering, Singapore

ABSTRACT

Mei Jun Jolene Liu¹, Siaw Meng Chou¹, Chee Kai Chua¹, Chia Meng Benjamin Tay² and Beng Koon Ng²

¹Nanyang Technological University, School of Mechanical and Aerospace Engineering, Singapore

²School of Electrical and Electronic Engineering, Singapore