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doi:10.3850/978-981-08-7615-9_TE05
Mechanical Tensile Strain Stimulation of Chondrocytes and Meniscus Cells in Thermo-Responsive Hydrogel
Jyh-Ping Chen1 and Tai-Hong Cheng2
1Department of Chemical and materials Engineering, 259 Wen Hwa 1st Rd.,Kwei-San, Taiyuan, Taiwan 333, R.O.C.
2Department of Products, Taiwan Textile Research Institute, 6 Cheng-Tian Rd., Tucheng, Taipei 236, Taiwan, R.O.C.
ABSTRACT
Temperature-responsive hydrogel scaffold containing chitosan and hyaluronic acid was used to entrap primary chondrocytes and meniscus cells. The effect of dynamic tensile strain on the cells/hydrogel constructs was evaluated by measuring cell proliferation, biosynthetic activity, and viability. The results demonstrated that mechanical deformation resulted in substantial increase in glycosaminoglycan and collagen productions over static controls while not significantly affecting cell proliferation and viability.
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