Selective Laser Sintering of Polycaprolactone Coated with Gelatin for Cartilage Tissue Engineering

doi:10.3850/978-981-08-7615-9_TE03

Selective Laser Sintering of Polycaprolactone Coated with Gelatin for Cartilage Tissue Engineering

Chih-Hao Chen¹, Jyh-Ping Chen¹ and Ming-Yih Lee²

¹Department of Chemical and Materials Engineering, Chang Gung University, Kwei-San, Taoyuan 333, Taiwan, ROC

²Graduate Institute of Medical Mechatronics, Chang Gung University, Kwei-San, Taoyuan 333, Taiwan, ROC

ABSTRACT

The purpose of this study was to investigate the attachment and proliferation of cells on selective laser-sintered (SLS) polycaprolactone (PCL) scaffolds coated with gelatin for cartilage tissue engineering using chondrocytes isolated from the articular cartilage of swine. Scaffolds without modification were used as control groups. Cell proliferation was measured by cell count 1, 3 and 5 days after cell seeding into the scaffolds. The biocompatibility of the scaffold was examined by scanning electron microscopy (SEM). The PCL scaffolds coated with gelatin had higher hydrophilicity. The results provided a useful strategy for modifying the microenvironments to increase cell attachment, growth and the formation of extracellular matrix on scaffolds for cartilage tissue engineering.

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Selective Laser Sintering of Polycaprolactone Coated with Gelatin for Cartilage Tissue Engineering

Chih-Hao Chen1, Jyh-Ping Chen1 and Ming-Yih Lee2

1Department of Chemical and Materials Engineering, Chang Gung University, Kwei-San, Taoyuan 333, Taiwan, ROC

2Graduate Institute of Medical Mechatronics, Chang Gung University, Kwei-San, Taoyuan 333, Taiwan, ROC

ABSTRACT

Chih-Hao Chen¹, Jyh-Ping Chen¹ and Ming-Yih Lee²

¹Department of Chemical and Materials Engineering, Chang Gung University, Kwei-San, Taoyuan 333, Taiwan, ROC

²Graduate Institute of Medical Mechatronics, Chang Gung University, Kwei-San, Taoyuan 333, Taiwan, ROC