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doi:10.3850/978-981-08-7615-9_FI07
The 3-D Imaging Guidance System for the Ultrasound Treatment System on Animal with Parkinson’s Disease
Jiann-Der Lee1, Yi-Hsuan Chu1, Yao Y. Shieh1, Hao-Li Liu1 and Kun-Ju Lin2
1Department of Electrical Engineering, Chang Gung University, Taiwan
2Department of Nuclear Medicine, Chang Gung Memorial Hospital, Taiwan
ABSTRACT
This paper presents a prototype system for using high-intensity focusedultrasound (HIFU) to treat the PD mouse under the designed stereotactic guidance. More specifically, the proposed system utilizes stereotactic guidance in concert with the technique of multi-modality SPECT/MRI registration. It comprises two key components: an automatic atlas-based SPECT/MR image registration module and a stereotactic positioning module. The reason for using SPECT/MR image registration here is because that imaging of dopamine transporters using 99mTc-TRODA-1 has been successfully applied to mice for the purpose of diagnosis of Parkinson’s disease. From the experimental results, the proposed automatic image registration module proves to have comparable performance to that derived from manual drawing by experts. In general, the stereotactic positioning module achieved a positioning accuracy to within 2mm on the average, which is acceptable for the purpose of HIFU treatment.
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