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doi:10.3850/978-981-08-7615-9_BS07
Noninvasive Diffuse Optical Measurement of Hemodynamic Parameters During Photodynamic Therapy
Jing Dong1, Jun Hui Ho1, Siong Luong Ting1, Patricia S. P. Thong2 and Kijoon Lee1
1Division of Bioengineering, School of Chemical & Biomedical Engineering, Nanyang Technological University, 70 Nanyang Drive, 637459, Singapore
2National Cancer Center Singapore, 11 Hospital Drive, 169610, Singapore
ABSTRACT
We present a novel multi-modal portable instrument incorporating both diffuse correlation spectroscopy (DCS) and diffuse optical spectroscopy (DOS), which enables simultaneous monitoring hemodynamic changes in deep tissue and provides a real-time feedback on therapeutic efficacy. By applying this instrument, a pilot experiment based on a predefined PDT protocol which uses Chlorine e6 (Ce6) as the photosensitizer, has been performed. The results showed that Ce6-mediated PDT treatment reduce the blood flow and blood oxygen saturation and increase the total hemoglobin concentration. These preliminary results suggest diffuse optical measurements permit real-time non-invasive monitoring the in vivo hemodynamic changes, thereby enabling early prediction of treatment efficacy of PDT.
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