Compare to concrete or steel material, timber construction contributes much less carbon footprint and having less self-weight. The use of timber as material construction has not been widely used in several seismic region countries due to the questioning of its seismic resistance. Researches has shown that the main element of CLT shear wall to resist lateral loading is its connection. To have a confidence of CLT shear wall application, uncertainty in shear wall connection need to be considered during the design stage. This study proposes a framework to design CLT shear wall structure considering uncertainty in its connections. This study consists of three parts. The first part is to build a nonlinear link element that could represent CLT hysteresis connection behavior under seismic. It requires calibrating numerical model to comply experimental result. Second stage is to build a numerical model of the CLT wall structure. Beside structure modelling, method to evaluate model subjected to seismic will also be defined. In this case, NTHA(Nonlinear Time History Analysis) will be carried out. Third part is integrating the numerical model into reliability assessment method. For this purpose, M-IS (Multisphere Importance Sampling) used to evaluate the reliability index. Proposed framework has purpose to give design framework of CLT subjected to seismic loading while account connection uncertainty.