More than 90% of the world's trade moves by sea, making the continuous operation of maritime ports a critical piece of the global economy. Unfortunately, many of the world's large ports are located in areas of high seismicity, and different components of ports such as wharves and cranes are vulnerable to seismic loading. Therefore, understanding and evaluating the seismic resilience of ports is important. Most previous studies on the seismic performance of ports have either focused on evaluating their component-based fragility or employ detailed but often unvalidated models which might not be suitable for practical assessment of the seismic resilience of ports on a regional-scale. In this paper, a practical framework is developed for evaluating the seismic resilience of ports. The framework is validated based on functional recovery durations of ports from historical seismic events. The resilience is characterized using systemlevel functionality curves, which provide the probabilities of functionality as a function of time following the earthquake. A componentbased approach is used by explicitly considering the number of components within a port and its redundancy. Different levels of functionalities such as partial and full functionality levels are considered. The framework is then applied to a port located in a highly seismic region in the US, and its resilience is evaluated over hazards with different return periods. The framework developed in this study can be used for efficient estimation of the seismic resilience of ports on a regional-scale and a global-scale.