Proceedings of the
9th International Conference of Asian Society for Precision Engineering and Nanotechnology (ASPEN2022)
15 – 18 November 2022, Singapore
doi:10.3850/978-981-18-6021-8_OR-01-0289
Manufacturing of Meso-Fluidic Devices for Life Science Application Using Biocompatible MJF Process
1HP-NTU Digital Manufacturing Corporate Lab, Nanyang Technological University, 50 Nanyang Ave, Singapore, 639798
2School of Mechanical & Aerospace Engineering, Nanyang Technological University, 50 Nanyang Ave Singapore 639798, Singapore
3Developmental Biology & Regenerative Medicine, LKC School of Medicine, 50 Nanyang Ave Singapore 639798, Singapore
4Lee Kong Chian School of Medicine, 50 Nanyang Ave Singapore 639798, Singapore
ABSTRACT
Multi Jet Fusion (MJF) is a recently developed industrial 3-dimensional (3D) printing process that produces functional prototypes and end-use production parts. This printing method is used for the production of biocompatible materials for research focusing on life science and invitro diagnostics. Polyamide - nylon 12 (PA-12) is the most tested material for additive manufacturing. The meso-fluidic device manufacturing are evaluated based on printability, surface condition, product design and development. The invitro biocompatibility of MJF-printed PA-12 was investigated as a preliminary step to verify its potential as a bioreactor. In addition, the printed PA-12 was also explored for developing assays such as for serological testing for the invitro detection of enzyme-linked immunosorbent assay (ELISA) coronavirus disease 2019 (COVID-19) antibodies. Depending on the application, several chip designs were developed and fabricated.
Keywords: Additive Manufacturing, Biocompatible, Meso-Fluidic, Device, Multi Jet Fusion, PA-12
1HP-NTU Digital Manufacturing Corporate Lab, Nanyang Technological University, 50 Nanyang Ave, Singapore, 639798
2School of Mechanical & Aerospace Engineering, Nanyang Technological University, 50 Nanyang Ave Singapore 639798, Singapore
3Developmental Biology & Regenerative Medicine, LKC School of Medicine, 50 Nanyang Ave Singapore 639798, Singapore
4Lee Kong Chian School of Medicine, 50 Nanyang Ave Singapore 639798, Singapore
ABSTRACT
Multi Jet Fusion (MJF) is a recently developed industrial 3-dimensional (3D) printing process that produces functional prototypes and end-use production parts. This printing method is used for the production of biocompatible materials for research focusing on life science and invitro diagnostics. Polyamide - nylon 12 (PA-12) is the most tested material for additive manufacturing. The meso-fluidic device manufacturing are evaluated based on printability, surface condition, product design and development. The invitro biocompatibility of MJF-printed PA-12 was investigated as a preliminary step to verify its potential as a bioreactor. In addition, the printed PA-12 was also explored for developing assays such as for serological testing for the invitro detection of enzyme-linked immunosorbent assay (ELISA) coronavirus disease 2019 (COVID-19) antibodies. Depending on the application, several chip designs were developed and fabricated.
Keywords: Additive Manufacturing, Biocompatible, Meso-Fluidic, Device, Multi Jet Fusion, PA-12
