This article mainly introduced and analyzed the current situation of cables used in space and the influence of cable fluoride escaping in the hermetic cabin. The most consumable low frequency wire at present--C-XX series wire and cable were selected, and it analyzed the influence factors of fluoride escaping in the X-ETFE. Fluoride escaping testing program base on the space situation were designed, and the testing results were systematically analyzed. At last, the key factors of cable fluoride escaping, were determined in order to provide theoretical basis and research direction for the space chosen of low fluoride escaping cable.