Seismic risk analysis and management of civil infrastructure systems has undergone an increasing interest among researchers in the recent past. Different methods and approaches have been proposed mainly dealing with the earthquake response of buildings and lifelines. Concerning transportation networks, most of the efforts focuses on the response of bridge stocks to specific earthquake scenarios, but very few examples exist examining the response of transportation networks as a whole. In particular, methods taking into account local site effects induced by liquefaction of the foundation soil are not developed yet. In this paper a novel framework is proposed to estimate the risk given by liquefaction on a road network within the more general EU project Liquefact. The study combines geotechnical analyses and the assessment of the traffic conditions to define hazard, vulnerability and exposure of the transportation network. The methodology has been applied to a rural area located in the district of Terre del Reno (Emilia Romagna, Italy) struck in 2012 by a seismic sequence that produced extensive liquefaction. The micro-zonation of liquefaction potential and the modelling of the transportation network are coupled to assess risk and identify mitigation strategies.