Extracorporeal Shock Wave Lithotripsy (ESWL) has been proven effective and become popular in fragmenting urological calculi noninvasively since its invention in the 1980s. One of the major mechanisms is the bubble cavitation generated by Shock Wave (SW) around the stone surface. In order to improve the stone comminution efficiency, a novel therapeutic strategy was proposed and tested in this study. Low-Intensity Pulsed Ultrasound (LIPUS) was delivered to the focal region of SWs during their intervals. Acoustic emission signals of bubble activities and light transmission through the focal region were measured by Passive Cavitation Detection (PCD) and a photo-detector, respectively. Bubble collapse time and the negative peak in the light transmission increased significantly as compared with SWs alone (166.7 ± 37.6 s vs. 95.4 ± 20.8 s and 1.78 ± 0.66 V vs. 0.77 ± 0.22 V, respectively