Geological situation and/or anthropogenic contamination contain an increased concentration of ions such as hexavalent chromium as well as some other dissolved components such as sulfate in the upper of the established MCLs. In this paper, simultaneous removal of Cr (VI) and sulfate from water was investigated using nanofiltration as a possible alternative to the conventional methods for varying pressure, pH and concentration. Sulfate and Cr (VI) concentration which have chosen were levels found in drinking water sources (Cr=0.1-0.5mg L-1) and (SO4-2= 100-800mg L-1). Experimental results indicated that, a better rejection of Cr (VI) (96%) was obtained at natural pH (7.5) and for an optimal of 4 bars. Permeate fluxes were 12.8 and 10.53L/m2.h at 4 bars in 0.1 and 0.5concentrations of Cr (VI) respectively. In presence of fixed sulfate concentration, fluxes declines with increasing ionic strength of Cr (VI) feed solutions. Simultaneous rejection of sulfate and Cr (VI) which varies 90% to 100% showed that the influences of the ionic strength of mixed aqueous solution were found weak in selected concentrations of both sulfate and Cr (VI). The observed retention sequence for the membrane examined is: SO4-2>Cr2O4-2.