Climate and associated factors shape the life of the natives of a particular geographical region influencing the overall health status of an individual. Certain facets of climate change have culminated in the emergence of epidemics, destruction of forests, flooding of coastal areas and other fatalities. This has led to global repercussions largely affecting the ecosystem. The impact of climate change on oral health is of significant importance. Considering the rampant usage of smokeless tobacco and exposure to various amounts of solar radiation, the incidence of oral precancer and cancer is increasing amongst the younger generation in the Indian sub-continent. The increasing life expectancy in developing countries is gradually shifting the focus to geriatric medicine and dentistry. The public health infrastructure needs to be strengthened to adapt to the rapidly changing disease profile. Therefore, concerted efforts have to be made in order to understand these modifying factors. This would facilitate a harmonious balance to enable sustainable development and optimum overall health.