This paper focuses on providing resistance factors for the use of load and resistance factor design (LRFD) on axially-loaded driven offshore piles in clays. The Imperial College Pile (ICP) design method along with its high-quality database was used in the calibration of the resistance factors. The uncertainty levels of loads (dead and live loads) and resistances (pile base and shaft capacities) are different. Therefore, the resistance factor is proposed as a function of the base-to-shaft capacity ratio and the dead-to-live load ratio based on the reliability analysis results The resistance factors in the current American Petroleum Institute (API) LRFD recommended practice were back calculated from the compiled database of working stress designs of typical platforms. In this paper, the resistance factors, compatible with the load factors given in the API LRFD recommended practice, were calculated and proposed based on the reliability analysis results for two different target reliability indices. It was found that the resistance factor was more influenced by the base-to-shaft capacity ratio than by the dead-to-live load ratio.