Concrete filled steel tubular (CFST) members are well recognized for their excellent static and seismic performances. They combine beneficial aspects of the performance of steel and concrete materials and mitigate the need for additional concrete formwork. For these reasons, they are being increasingly used for high-rise building columns and bridge piers. Therefore, it is essential to understand how these structures will behave during and after a strong ground motion. This paper studies the effect of horizontal near fault ground motions on frames with rectangular CFST columns and steel I girders. Several multi-story moment resisting frames (MRF) with 3, 5, 7, 10 and 12 stories are examined. In these models, confinement of the internal concrete and local buckling of the steel tube is considered. It is shown that there is a significant increase in the responses from the near-fault ground motions compared to the far field ground motions considered. In addition, it is shown that the vertical component of near-fault ground motion can have significant effect on the response of CFST columns.